Qiqi Liu, Chunyu Wang, Mingsheng Zhu, Jinming Liu, Qiannan Duan, Adam C. Midgley, Ruming Liu, Bing Jiang, Deling Kong, Quan Chen, Jie Zhuang, Xinglu Huang
Self-Assembly of Heterogeneous Ferritin Nanocages for Tumor Uptake and Penetration.
Advanced Science
Mingsheng Zhu, Jie Zhuang, Zhe Li, Qiqi Liu, Zhanxia Gao, Adam Midgley, Tianyi Qi, Rongping Zhao, Zhixuan Zhang, Deling Kong, Jie Tian, Xiyun Yan, Xinglu Huang
Machine Learning-assisted Single Vessel Analysis of Nanoparticle Permeability in Tumour Vasculatures.
Nature Nanotechnology
Yuanke Li, Haoqi Zhang, Ruikun Wang, Yuan Wang, Ruonan Li, Mingsheng Zhu, Xiangyun Zhang, Zhen Zhao, Yajuan Wan, Jie Zhuang, Hongkai Zhang, Xinglu Huang
Tumor Cell Nanovaccines Based on Genetically Engineered Antibody‐Anchored Membrane.
Advanced Materials
Jie Zhuang, Adam C. Midgley, Yonghua Wei, Qiqi Liu, Deling Kong, Xinglu Huang
Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes.
Advanced Materials
Chunyu Wang, Qiqi Liu, Xinglu Huang, Jie Zhuang
Ferritin Nanocage: A Versatile Platform for Nanozyme Design.
Journal of Materials Chemistry B
Fan Yu, Qianping Zhang, Hanyu Liu, Jinming Liu, Song Yang, Xiaofan Luo, Wei Liu, Hao Zheng, Qiqi Liu, Yunxi Cui, Guo Chen, Yanjun Li, Xinglu Huang, Xiyun Yan, Jun Zhou, Quan Chen
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis.
Cell Discovery
Yonghua Wei, Jin Wu, Yixuan Wu, Hongjiang Liu, Fanqiang Meng, Qiqi Liu, Adam C Midgley, Xiangyun Zhang, Tianyi Qi, Helong Kang, Rui Chen, Deling Kong, Jie Zhuang, Xiyun Yan, Xinglu Huang
Prediction and Design of Nanozymes Using Explainable Machine Learning.
Advanced Materials
Zhijun Liu, Qiqi Liu, Haoqi Zhang, Xiangyun Zhang, Jin Wu, Zhiyuan Sun, Mingsheng Zhu, Xueyan Hu, Tianyi Qi, Helong Kang, Rui Chen, Xinglu Huang, Jie Zhuang
Genetically Engineered Protein Corona-based Cascade Nanozymes for Enhanced Tumor Therapy.
Advanced Functional Materials
Xiaohua Jia, Guodong Shen, Jia Jia, Yan Zhang, Dan Zhang, Wanjun Li, Jianjun Zhang, Xinglu Huang, Jie Tian
Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells.
Biosensors
Jiacong Gao, Xueyan Hu, Congjuan Xu, Mingming Guo, Shouyi Li, Fan Yang, Xiaolei Pan, Fangyu Zhou, Yongxin Jin, Fang Bai, Zhihui Cheng, Zhenzhou Wu, Shuiping Chen, Xinglu Huang, Weihui Wu
Neutrophil Mediated Delivery of the Combination of Colistin and Azithromycin for the Treatment of Bacterial Infection.
iScience
Bai Xue, Mengyue Ge, Kelong Fan, Xinglu Huang, Xiyun Yan, Wei Jiang, Bing Jiang, Zhenglin Yang
Mitochondria-targeted nanozymes eliminate oxidative damage in retinal neovascularization disease.
Journal of Controlled Release
Jin Wu, Yonghua Wei, Jingping Lan, Xueyan Hu, Fangli Gao, Xiangyun Zhang, Zhanxia Gao, Qiqi Liu, Zhiyuan Sun, Rui Chen, Hanqing Zhao, Kelong Fan, Xiyun Yan, Jie Zhuang, Xinglu Huang
Screening of Protein-Based Ultrasmall Nanozymes for Building Cell-Mimicking Catalytic Vesicles.
Small
Xinbang Jiang, Xiangyun Zhang, Chen Guo, Yameng Yu, Boya Ma, Zhuang Liu, Yamin Chai, Lichun Wang, Yunzheng Du, Biao Wang, Nan Li, Dong Dong, Yueguo Li, Xinglu Huang, Lailiang Ou
Protein corona-coated immunomagnetic nanoparticles with enhanced isolation of circulating tumor cells.
Nanoscale
Jinghua Han, Wei Yang, Yuanke Li, Jianwen Li, Fangchao Jiang, Jin Xie, and Xinglu Huang
Combining Doxorubicin-Conjugated Polymeric Nanoparticles and 5-Aminolevulinic Acid for Enhancing Radiotherapy against Lung Cancer.
Bioconjugate Chemistry
Zhiyuan Sun, Qiqi Liu, Xinyue Wang, Jin Wu, Xueyan Hu, Miaomiao Liu, Xiangyun Zhang, Yonghua Wei, Zhijun Liu, Hongjiang Liu, Rui Chen, Fei Wang, Adam C. Midgley, Aitao Li, Xiyun Yan, Yanming Wang, Jie Zhuang, Xinglu Huang
Bioorthogonal catalytic nanozyme-mediated lysosomal membrane leakage for targeted drug delivery.
Theranostics
Xiangyun Zhang, Yue Zhang, Ran Zhang, Xinbang Jiang, Adam C Midgley, Qiqi Liu, Helong Kang, Jin Wu, Anila Khalique, Meng Qian, Di An, Jing Huang, Lailiang Ou, Qiang Zhao, Jie Zhuang, Xiyun Yan, Deling Kong, Xinglu Huang
Biomimetic Design of Artificial Hybrid Nanocells for Boosted Vascular Regeneration in Ischemic Tissues
Advanced Materials
Qiqi Liu, Jingwei Tian, Jinjian Liu, Mingsheng Zhu, Zhanxia Gao, Xueyan Hu, Adam C Midgley, Jin Wu, Xinyue Wang, Deling Kong, Jie Zhuang, Jianfeng Liu, Xiyun Yan, Xinglu Huang
Modular Assembly of Tumor-Penetrating and Oligomeric Nanozyme Based on Intrinsically Self-Assembling Protein Nanocages
Advanced Materials
Xueyan Hu, Xinyue Wang, Qiqi Liu, Jin Wu, Haoqi Zhang, Anila Khalique, Zhiyuan Sun, Rui Chen, Jing Wei, Hongbo Li, Deling Kong, Jie Zhuang, Xiyun Yan, and Xinglu Huang
Nanozyme-Powered Giant Unilamellar Vesicles for Mimicry and Modulation of Intracellular Oxidative Stress
ACS Applied Materials & Interfaces
Zhang, Yue; Khalique, Anila; Du, Xinchen; Gao, Zhanxia; Wu, Jin; Zhang, Xiangyun; Zhang, Ran; Sun, Zhiyuan; Liu, Qiqi; Xu, Zhelong; Midgley, Adam C.; Wang, Lianyong; Yan, Xiyun; Zhuang, Jie; Kong, Deling; Huang, Xinglu
Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers
Advanced Materials
Zhiyuan Sun, Haoqi Zhang, Jin Wu, Fangli Gao, Congcong Zhang, Xueyan Hu, Qiqi Liu, Yonghua Wei, Jie Zhuang, and Xinglu Huang
A Novel Model System for Understanding Anticancer Activity of Hypoxia-Activated Prodrugs
Molecular Pharmaceutics
Zhang, Ran; Luo, Wenya; Zhang, Yue; Zhu, Dashuai; Midgley, Adam C.; Song, Hao; Khalique, Anila; Zhang, Haoqi; Zhuang, Jie; Kong, Deling; Huang, Xinglu
Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases
Science Advances
Gao, Fangli; Wu, Jin; Gao, Heqi; Hu, Xueyan; Liu, Lihua; Midgley, Adam C.; Liu, Qiqi; Sun, Zhiyuan; Liu, Yijin; Ding, Dan; Wang, Yanming; Kong, Deling; Huang, Xinglu
Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics
Biomaterials
Huang X, Zhuang J, Chung SW, Huang B, Halpert G, Negron K, Sun X, Yang J, Oh Y, Hwang PM, Hanes J, Suk JS.
Hypoxia-Tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia.
ACS Nano. 2019, 13 (1), pp 236–247
Huang X, Chisholm J, Zhuang J, Xiao Y, Parikh K, Zhang C, Chen X, Suk JS, Hanes J.
Protein Nanocages that penetrate airway mucus and tumor tissue.
Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6595-E6602.
Choi KY,* Silvestre OF,* Huang X,* Hida N, Liu G, Ho DN, Lee S, Lee SW, Hong JI, Chen X.
A nanoparticle formula for delivering siRNA or miRNAs to tumor cells in cell culture and in vivo.
Nature Protoc. 2014, 9(8):1900-15. (*Equally contributed)
Huang X,* Zhang F,* Wang Y, Sun X, Choi KY, Liu D, Cheon J, Niu G, Chen X.
Design consideration of iron-based nanoclusters for non-invasive tracking mesenchymal stem cell homing.
ACS Nano. 2014, 8(5):4403-14.
Sun X,* Huang X,* Guo J, Niu G, Zhu W, Kiesewetter DO, Sun S, Chen X.
Self-illuminating 64Cu doped CdSe/ZnS QDs for in vivo tumor imaging.
J Am Chem Soc. 2014, 136(5):1706-9. (*Equally contributed)
Huang X, Zhang F, Sun X, Choi KY, Niu G, Zhang G, Guo J, Lee S, Chen X.
The genotype-dependent influence of functionalized multiwalled carbon nanotubes on fetal development
Biomaterials. 2014, 35(2): 856-865.
Huang X, Zhang F, Zhu L, Choi KY, Guo N, Guo J, Tackett K, Anilkumar P, Liu G, Quan Q, Choi HS, Niu G, Sun Y, Lee S, Chen X.
Effect of injection routes on the biodistribution, clearance, and tumor uptake of carbon dots.
ACS Nano. 2013, 7(7):5684-93.
He J,* Huang X,* Li YC, Liu Y, Babu T, Aronova MA, Wang S, Lu Z, Chen X, Nie Z.
Self-Assembly of Amphiphilic Plasmonic Micelle-Like Nanoparticles in Selective Solvents.
J Am Chem Soc. 2013, 135(21):7974-7984. (*Equally contributed)
Huang X, Zhang F, Wang H, Niu G, Choi KY, Swierczewska M, Zhang G, Gao H, Wang Z, Zhu L, Choi HS, Lee S, Chen X.
Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery.
Biomaterials. 2013, 34(7):1772-80.
Zhang F,* Huang X,* Zhu L, Guo N, Niu G, Swierczewska M, Lee S, Xu H, Wang AY, Mohamedali KA, Rosenblum MG, Lu G, Chen X.
Noninvasive monitoring of orthotopic glioblastoma therapy response using RGD-conjugated iron oxide nanoparticles.
Biomaterials. 2012, 33(21):5414-22. (*Equally contributed)
Huang X, Zhang F, Lee S, Swierczewska M, Kiesewetter D, Lang L, Zhang G, Zhu L, Gao H, Leapman R, Niu G, Chen X.
Long-term Multimodal Imaging of Tumor Draining Sentinel Lymph Nodes using Mesoporous Silica-based Nanoprobes.
Biomaterials. 2012, 33(17):4370-8.
Huang X, Swierczewska M, Choi K, Zhu L, Bhirde A, Park J, Kim K, Xie J, Niu G, Lee K, Lee S, Chen X.
Multiplex Imaging of Intracellular Proteolytic Cascade Using a Broad Spectrum Nano-Quencher.
Angew Chem Int Ed Engl. 2012, 51(7):1625-30.
Huang X,* Li L,* Liu T, Hao N, Liu H, Chen D, Tang F.
The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance and Biocompatibility in vivo.
ACS Nano. 2011, 5(7):5390-9.
Huang X, Zhuang J, Teng X, Li L, Chen D, Yan X, Tang F.
Mesoporous Silica Nanoparticles Promote Human Malignant Melanoma growth by Decreasing Reactive Oxygen Species: a signal transduction mechanism.
Biomaterials. 2010, 31:6142-6153.
Huang X, Teng X, Chen D, Tang F, He J.
The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function.
Biomaterials. 2010, 31:438–448