研究成果
Publications
2025
Modular Design of T Cell Nanoengagers for Tumor Immunotherapy via Genetically Engineered Lipid‐Tagged Antibody Fragments
Helong Kang, Yuanke Li, Fude Sun, Fan Li, Mingsheng Zhu, Zheng Zhou, Jin Wu, Keyu Wang, Buayishamu Kutilike, Zhizhao Miao, Yanqin Xu, Ruming Liu, Dan Ding, Hongkai Zhang, Xinglu Huang, Jie Zhuang
Advanced Materials
Synthetic Biology‐Based Strategy for Nanomedicine Design
Xiangyun Zhang, Qiannan Duan, Jie Zhuang, Xinglu Huang
Small Methods
Fine‐tuning electron transfer for nanozyme design
Xia Zong, Xinran Xu, Dai‐Wen Pang, Xinglu Huang, An‐An Liu
Advanced Healthcare Materials
Assembly of Genetically Engineered Ionizable Protein Nanocage-based Nanozymes for Intracellular Superoxide Scavenging
Qiqi Liu, Zhanxia Gao, Xiangyun Zhang, Qiannan Duan, Yue Zhang, Adam C Midgley, Li Jiao, Ruming Liu, Mingsheng Zhu, Deling Kong, Jie Zhuang, Xinglu Huang
Nature Communications
Rational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors
Mingsheng Zhu, Qiqi Liu, Zhengbang Chen, Jinming Liu, Zhixuan Zhang, Jingwei Tian, Xiangyang Wang, Xiong Yang, Quan Chen, Xinglu Huang, Jie Zhuang
ACS Nano
2024
Design of Artificial Extracellular Vesicles for Treatments of Cardiovascular Diseases
Yingqi Miao, Xinglu Huang
Extracellular Vesicle: Biology and Translational Application
Rational Design of Genetically Engineered Mitochondrial-Targeting Nanozymes for Alleviating Myocardial Ischemic-Reperfusion Injury
Xiangyun Zhang, Qiqi Liu, Rongping Zhao, Zhihua Pang, Weiyu Zhang, Tianyi Qi, Mingsheng Zhu, Helong Kang, Meng Qian, Yajuan Wan, Rui Wang, Shufang Wang, Xinglu Huang, Jie Zhuang
Nano Letters
Data‐Driven Design of Triple‐Targeted Protein Nanoprobes for Multiplexed Imaging of Cancer Lymphatic Metastasis
Guodong Shen, Xiaohua Jia, Tianyi Qi, Zhenhua Hu, Anqi Xiao, Qiqi Liu, Keyu He, Weihong Guo, Dan Zhang, Wanjun Li, Genmao Cao, Guoxin Li, Jie Tian, Xinglu Huang, Yanfeng Hu
Advanced Materials
Greatly isolated heterogeneous circulating tumor cells using hybrid engineered cell membrane-camouflaged magnetic nanoparticles
Xinbang Jiang, Xiangyun Zhang, Chen Guo, Zhuang Liu, Xiaofang Guo, Ziying Tian, Zimeng Wang, Jingxuan Yang, Xinglu Huang, Lailiang Ou
Journal of Nanobiotechnology
Self-Assembly of Heterogeneous Ferritin Nanocages for Tumor Uptake and Penetration.
Qiqi Liu, Chunyu Wang, Mingsheng Zhu, Jinming Liu, Qiannan Duan, Adam C. Midgley, Ruming Liu, Bing Jiang, Deling Kong, Quan Chen, Jie Zhuang, Xinglu Huang
Advanced Science
Genetically engineered membrane-based nanoengagers for immunotherapy of pancreatic cancer
Haoqi Zhang, Yuanke Li, Helong Kang, Jingping Lan, Lin Hou, Zhengbang Chen, Fan Li, Yanqin Liu, Jiliang Zhao, Na Li, Yajuan Wan, Yiping Zhu, Zhen Zhao, Hongkai Zhang, Jie Zhuang, Xinglu Huang
Journal of Nanobiotechnology
Machine‐Learning‐Assisted Nanozyme Design: Lessons from Materials and Engineered Enzymes
Jie Zhuang, Adam C Midgley, Yonghua Wei, Qiqi Liu, Deling Kong, Xinglu Huang
Advanced Materials
Genetically Engineered Cell Membrane‐Coated Magnetic Nanoparticles for High‐Performance Isolation of Circulating Tumor Cells
Xinbang Jiang, Xiangyun Zhang, Chen Guo, Boya Ma, Zhuang Liu, Yunzheng Du, Biao Wang, Nan Li, Xinglu Huang, Lailiang Ou
Advanced Functional Materials
Deep learning technology in vascular image segmentation and disease diagnosis
Chengyang Du, Jie Zhuang, Xinglu Huang
Journal of Intelligent Medicine
Versatile Design of NO‐Generating Proteolipid Nanovesicles for Alleviating Vascular Injury
Yueyue Yang, Xiangyun Zhang, Hongyu Yan, Rongping Zhao, Ruixin Zhang, Liuyang Zhu, Jingai Zhang, Adam C Midgley, Ye Wan, Songdi Wang, Meng Qian, Qiang Zhao, Ding Ai, Ting Wang, Deling Kong, Xinglu Huang, Kai Wang
Advanced Science
2023
Machine Learning-assisted Single Vessel Analysis of Nanoparticle Permeability in Tumour Vasculatures.
Mingsheng Zhu, Jie Zhuang, Zhe Li, Qiqi Liu, Zhanxia Gao, Adam Midgley, Tianyi Qi, Rongping Zhao, Zhixuan Zhang, Deling Kong, Jie Tian, Xiyun Yan, Xinglu Huang
Nature Nanotechnology
Tumor Cell Nanovaccines Based on Genetically Engineered Antibody‐Anchored Membrane.
Yuanke Li, Haoqi Zhang, Ruikun Wang, Yuan Wang, Ruonan Li, Mingsheng Zhu, Xiangyun Zhang, Zhen Zhao, Yajuan Wan, Jie Zhuang, Hongkai Zhang, Xinglu Huang
Advanced Materials
Ferritin Nanocage: A Versatile Platform for Nanozyme Design.
Chunyu Wang, Qiqi Liu, Xinglu Huang, Jie Zhuang
Journal of Materials Chemistry B
2022
Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis.
Fan Yu, Qianping Zhang, Hanyu Liu, Jinming Liu, Song Yang, Xiaofan Luo, Wei Liu, Hao Zheng, Qiqi Liu, Yunxi Cui, Guo Chen, Yanjun Li, Xinglu Huang, Xiyun Yan, Jun Zhou, Quan Chen
Cell Discovery
Prediction and Design of Nanozymes Using Explainable Machine Learning.
Yonghua Wei, Jin Wu, Yixuan Wu, Hongjiang Liu, Fanqiang Meng, Qiqi Liu, Adam C Midgley, Xiangyun Zhang, Tianyi Qi, Helong Kang, Rui Chen, Deling Kong, Jie Zhuang, Xiyun Yan, Xinglu Huang
Advanced Materials
Genetically Engineered Protein Corona-based Cascade Nanozymes for Enhanced Tumor Therapy.
Zhijun Liu, Qiqi Liu, Haoqi Zhang, Xiangyun Zhang, Jin Wu, Zhiyuan Sun, Mingsheng Zhu, Xueyan Hu, Tianyi Qi, Helong Kang, Rui Chen, Xinglu Huang, Jie Zhuang
Advanced Functional Materials
Lineage Tracing and Molecular Real-Time Imaging of Cancer Stem Cells.
Xiaohua Jia, Guodong Shen, Jia Jia, Yan Zhang, Dan Zhang, Wanjun Li, Jianjun Zhang, Xinglu Huang, Jie Tian
Biosensors
Mitochondria-targeted nanozymes eliminate oxidative damage in retinal neovascularization disease.
Bai Xue, Mengyue Ge, Kelong Fan, Xinglu Huang, Xiyun Yan, Wei Jiang, Bing Jiang, Zhenglin Yang
Journal of Controlled Release
Screening of Protein-Based Ultrasmall Nanozymes for Building Cell-Mimicking Catalytic Vesicles.
Jin Wu, Yonghua Wei, Jingping Lan, Xueyan Hu, Fangli Gao, Xiangyun Zhang, Zhanxia Gao, Qiqi Liu, Zhiyuan Sun, Rui Chen, Hanqing Zhao, Kelong Fan, Xiyun Yan, Jie Zhuang, Xinglu Huang
Small
Protein corona-coated immunomagnetic nanoparticles with enhanced isolation of circulating tumor cells.
Xinbang Jiang, Xiangyun Zhang, Chen Guo, Yameng Yu, Boya Ma, Zhuang Liu, Yamin Chai, Lichun Wang, Yunzheng Du, Biao Wang, Nan Li, Dong Dong, Yueguo Li, Xinglu Huang, Lailiang Ou
Nanoscale
Combining Doxorubicin-Conjugated Polymeric Nanoparticles and 5-Aminolevulinic Acid for Enhancing Radiotherapy against Lung Cancer.
Jinghua Han, Wei Yang, Yuanke Li, Jianwen Li, Fangchao Jiang, Jin Xie, and Xinglu Huang
Bioconjugate Chemistry
Bioorthogonal catalytic nanozyme-mediated lysosomal membrane leakage for targeted drug delivery.
Zhiyuan Sun, Qiqi Liu, Xinyue Wang, Jin Wu, Xueyan Hu, Miaomiao Liu, Xiangyun Zhang, Yonghua Wei, Zhijun Liu, Hongjiang Liu, Rui Chen, Fei Wang, Adam C. Midgley, Aitao Li, Xiyun Yan, Yanming Wang, Jie Zhuang, Xinglu Huang
Theranostics
Biomimetic Design of Artificial Hybrid Nanocells for Boosted Vascular Regeneration in Ischemic Tissues
Xiangyun Zhang, Yue Zhang, Ran Zhang, Xinbang Jiang, Adam C Midgley, Qiqi Liu, Helong Kang, Jin Wu, Anila Khalique, Meng Qian, Di An, Jing Huang, Lailiang Ou, Qiang Zhao, Jie Zhuang, Xiyun Yan, Deling Kong, Xinglu Huang
Advanced Materials
2021
Modular Assembly of Tumor-Penetrating and Oligomeric Nanozyme Based on Intrinsically Self-Assembling Protein Nanocages
Qiqi Liu, Jingwei Tian, Jinjian Liu, Mingsheng Zhu, Zhanxia Gao, Xueyan Hu, Adam C Midgley, Jin Wu, Xinyue Wang, Deling Kong, Jie Zhuang, Jianfeng Liu, Xiyun Yan, Xinglu Huang
Advanced Materials
Nanozyme-Powered Giant Unilamellar Vesicles for Mimicry and Modulation of Intracellular Oxidative Stress
Xueyan Hu, Xinyue Wang, Qiqi Liu, Jin Wu, Haoqi Zhang, Anila Khalique, Zhiyuan Sun, Rui Chen, Jing Wei, Hongbo Li, Deling Kong, Jie Zhuang, Xiyun Yan, and Xinglu Huang
ACS Applied Materials & Interfaces
Biomimetic Design of Mitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers
Yue Zhang, Anila Khalique, Xinchen Du, Zhanxia Gao, Jin Wu, Xiangyun Zhang, Ran Zhang, Zhiyuan Sun, Qiqi Liu, Zhelong Xu, Adam C Midgley, Lianyong Wang, Xiyun Yan, Jie Zhuang, Deling Kong, Xinglu Huang
Advanced Materials
2020
A Novel Model System for Understanding Anticancer Activity of Hypoxia-Activated Prodrugs
Zhiyuan Sun, Haoqi Zhang, Jin Wu, Fangli Gao, Congcong Zhang, Xueyan Hu, Qiqi Liu, Yonghua Wei, Jie Zhuang, and Xinglu Huang
Molecular Pharmaceutics
Particle-based artificial three-dimensional stem cell spheroids for revascularization of ischemic diseases
Ran Zhang, Wenya Luo, Yue Zhang, Dashuai Zhu, Adam C Midgley, Hao Song, Anila Khalique, Haoqi Zhang, Jie Zhuang, Deling Kong, Xinglu Huang
Science Advances
Hypoxia-tropic nanozymes as oxygen generators for tumor-favoring theranostics
Fangli Gao, Jin Wu, Heqi Gao, Xueyan Hu, Lihua Liu, Adam C Midgley, Qiqi Liu, Zhiyuan Sun, Yijin Liu, Dan Ding, Yanming Wang, Deling Kong, Xinglu Huang
Biomaterials